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KMID : 1197720140070010028
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대한파킨슨병 및 이상운동질환 학회지
2014 Volume.7 No. 1 p.28 ~ p.30
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Suppression of Myoclonus in Corticobasal Degeneration by Levetiracetam
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Cho Jae-Wook
Lee Jae-Hyeok
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Abstract
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Myoclonus in corticobasal degeneration (CBD) has often been associated with severe and difficult to treat disabilities. Levetiracetam is a new antiepileptic agent with antimyoclonic effects. Herein, we present a 72-year-old woman with clinically probable CBD and with spontaneous rhythmic myoclonus in the right foot, which was markedly ameliorated through treatment with levetiracetam. The effect of levetiracetam was associated with the decreased amplitude of enlarged cortical somatosensory evoked potentials. This result suggests that the antimyoclonic effect of levetiracetam might be mediated through the suppression of increased cortical excitability.
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KEYWORD
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WordsaaCorticobasal degeneration, Myoclonus, Levetiracetam
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